N-Hydroxysuccinimide (NHS) is an important organic synthesis and pharmaceutical research reagent widely used in peptide synthesis, amide coupling, bioconjugation, and the preparation of N-hydroxysuccinimide ester deriva…
N-Hydroxysuccinimide (NHS) is an important organic synthesis and pharmaceutical research reagent widely used in peptide synthesis, amide coupling, bioconjugation, and the preparation of N-hydroxysuccinimide ester derivatives. Chemically known as 1-Hydroxy-2,5-pyrrolidinedione, it contains a reactive hydroxyl group attached to a succinimide ring, making it particularly useful for activating carboxylic acids and facilitating efficient coupling reactions. Its well-established reactivity makes N-Hydroxysuccinimide an important material for pharmaceutical research, biochemical applications, organic synthesis, and specialty chemical development.
N-Hydroxysuccinimide is commonly used in combination with carbodiimide coupling reagents for the formation of activated NHS esters from carboxylic acids. These activated esters can subsequently react with amines to form amide bonds, making NHS particularly valuable in peptide coupling, protein modification, labeling chemistry, and the preparation of functionalized pharmaceutical intermediates. It is also used in the synthesis of various N-succinimidyl ester compounds and in research involving surface modification and bioconjugation.
NEXA IMPEX supplies N-Hydroxysuccinimide to pharmaceutical manufacturers, research laboratories, biotechnology companies, contract research organizations, contract development and manufacturing organizations, and specialty chemical manufacturers. The product is suitable for laboratory research, process development, peptide chemistry, pharmaceutical synthesis, analytical applications, and other qualified chemical manufacturing requirements.
NEXA IMPEX focuses on consistent product quality, reliable supply, controlled packaging, and technical documentation support. COA, MSDS/SDS, product specification sheets, TDS, and applicable analytical documentation can be provided according to customer requirements. The material is available for laboratory, development, and bulk procurement requirements with suitable packaging for domestic and international supply.
NEXA IMPEX supplies N-Hydroxysuccinimide in laboratory, development, and commercial quantities. Standard packaging may include 100 g, 500 g, 1 kg, 5 kg, 10 kg, and 25 kg, with customized packaging available according to customer requirements. Suitable sealed and moisture-protective packaging is used to help maintain product quality during storage and transportation.
Reference specification for NHS — confirm current certificate of analysis against your target pharmacopoeia at enquiry.
| Parameter | Specification |
|---|---|
| Assay | NLT 98.0% |
| pH (1% Solution) | 5.0–7.0 |
| Melting Point | 95–100°C |
| Molecular Formula | C₄H₅NO₃ |
| Molecular Weight | 115.09 g/mol |
| Storage | Store in a cool, dry place; protect from moisture |
Common questions from buyers evaluating NHS sourcing from NexaImpex.