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1-(5-Bromo-2-Methoxyphenyl)Adamantane, also known as 2-(1-Adamantyl)-4-bromoanisole, is a specialized aromatic adamantane derivative with CAS No. 104224-63-7. The compound has the molecular formula C₁₇H₂₁BrO and a molec…
1-(5-Bromo-2-Methoxyphenyl)Adamantane, also known as 2-(1-Adamantyl)-4-bromoanisole, is a specialized aromatic adamantane derivative with CAS No. 104224-63-7. The compound has the molecular formula C₁₇H₂₁BrO and a molecular weight of 321.26 g/mol. It consists of an adamantane moiety attached to a brominated methoxy-substituted phenyl ring, providing a structurally useful combination of a rigid adamantane framework and an aromatic bromide functionality.
1-(5-Bromo-2-Methoxyphenyl)Adamantane is a solid organic synthesis intermediate used in specialty chemical and pharmaceutical research. Commercial chemical references identify the compound as an intermediate associated with the synthesis of adapalene, while it is also used as a research reagent for further functionalization of the aromatic bromide and adamantane-containing molecular framework.
The compound is particularly useful when a synthetic route requires an aromatic bromine substituent that can participate in subsequent transformations. The brominated aromatic ring can serve as a functional handle for additional synthetic chemistry, while the adamantane group contributes a rigid, hydrophobic structural component. These characteristics make the material relevant to pharmaceutical intermediate development, medicinal chemistry, organic synthesis, and specialty chemical research.
1-(5-Bromo-2-Methoxyphenyl)Adamantane is a specialized organic compound combining a substituted anisole ring with an adamantane framework. The molecule contains a bromine atom and a methoxy group on the aromatic ring, together with an adamantyl substituent. This distinctive molecular architecture makes the compound useful as a building block for advanced organic synthesis and pharmaceutical research.
One of the important applications associated with 1-(5-Bromo-2-Methoxyphenyl)Adamantane is its role in synthetic routes related to adapalene, a retinoid pharmaceutical compound. Chemical reference sources describe this material as an adapalene intermediate and as an organic synthesis reagent for preparation of subsequent intermediates.
The aryl bromide functionality is particularly valuable from a synthetic chemistry perspective because it provides a reactive position for subsequent transformations. Depending on the intended synthetic route, aromatic bromides can be used in coupling and other functionalization reactions to introduce additional molecular fragments. Consequently, this compound can be valuable in process-development programs where controlled modification of an aromatic intermediate is required.
The adamantane group provides a rigid, three-dimensional hydrocarbon framework that is frequently incorporated into medicinal chemistry and pharmaceutical research. Its presence can influence molecular shape, lipophilicity, and steric characteristics, making adamantane-containing compounds of interest for the development and study of biologically active molecules and specialty chemical structures.
Commercial reference data describes 1-(5-Bromo-2-Methoxyphenyl)Adamantane as a solid. TCI specifies the product as >98.0% by GC, with a recommended storage condition of room temperature in a cool and dark place below 15°C. ChemicalBook reports a white solid form and a melting point around 139–141°C, although reported physical values can vary between sources and should be confirmed against the supplier's current specification and batch CoA.
For quality evaluation, customers may consider appearance, identification, assay/purity by GC, melting point, residual solvents, water content, and related substances, depending on the intended application. When this material is being used as an intermediate for further pharmaceutical synthesis, customer-specific analytical and quality requirements should be agreed before commercial supply.
1-(5-Bromo-2-Methoxyphenyl)Adamantane can be supplied in suitable packaging according to the required quantity, handling requirements, storage conditions, transportation requirements, and customer specifications. Packaging can be arranged for laboratory, R&D, pilot-scale, and commercial requirements.
Reference specification for 1-(5-Bromo-2-Methoxyphenyl)Adamantane — confirm current certificate of analysis against your target pharmacopoeia at enquiry.
| Parameter | Specification |
|---|---|
| Molecular Formula | C₁₇H₂₁BrO |
| Molecular Weight | 321.26 g/mol |
| Physical StatePhysical State | Solid |
| Purity by GC | >98.0% |
| Melting Point | Approx. 139–141°C |
| Storage | Room Temperature, Cool & Dark Place, <15°C Recommended |
Common questions from buyers evaluating 1-(5-Bromo-2-Methoxyphenyl)Adamantane sourcing from NexaImpex.